The Antiproteolytic Activity of Serum
نویسنده
چکیده
1. An equation is derived for the calculation of a constant which, experimental results indicate, may be a more reliable index of the antiproteolytic activity of serum than those equations hitherto used. 2. (a) Intramuscular administration of trypsin resulted in a slow rise in the antiproteolytic activity of the serum, followed by a lesser decline. (b) Intravenous administration resulted in no appreciable variation. (c) Oral administration resulted in a rapid rise, which was sustained during the period of administration. (d) Intramuscular, intravenous, or oral administration of denatured trypsin resulted in no appreciable variation. (e) The extent of the local necrosis following subcutaneous injection of trypsin varied inversely with the antiproteolytic activity of the serum. 3. The experimental results indicate that the products of protein hydrolysis in the intestine and parenterally are an important factor in the antiproteolytic activity of the serum. They also indicate that antibodies to trypsin are not an important factor in the antiproteolytic activity of the serum.
منابع مشابه
The Antiproteolytic Activity of Serum I. the Nature and Expe~tm-f.ntal Variation of the Antiproteolytic
Hildebrandt (1893), Camus and Gley (1897), and Landsteiner (1900) were the first investigators to observe that normal serum markedly inhibits the action of trypsin and of yeast proteases. Opie (1905) and Jochmann (1908) demonstrated its ability to inhibit leucoprotease. Study of numerous species of animals (Launoy, 1919) showed antiproteolytic activity to be a constant property of mammalian and...
متن کاملProteolytic inhibitors in serum. I. Effect of food intake and of hypophysectomy.
It has been known for many years that serum possesses the property of inhibiting several proteolytic enzymes (6, 10, 12, 20, 23). Many the ories as to the role of the serum inhibitors have been proposed (9); however, at present their source and function remain unknown. In 1908, Brieger and Trebling (1) reported that the antiproteolytic activity of serum was in creased by malignant disease. Sinc...
متن کاملMetalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1.
Tissue inhibitor of metalloproteinases-1 (TIMP-1), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibition by preparing purified TIMP-1 "knockout" proteins lacking in vitro antiproteo...
متن کاملObservations on the antiproteolytic reaction of the serum of mice; strain variations.
Variations in the antiproteolytic reaction of the serum have been observed in animals and in hu man patients. Variations among species have been recorded (1,2) but within a given species there is little variation in the reaction of normal animals except for the guinea pig in which moderate differ ences have been noted. So far as we know, no pre vious studies have been made in mice probably be c...
متن کاملMetalloproteinase Inhibition and Erythroid Potentiation Are Independent Activities of Tissue Inhibitor of Metalloproteinases - l
Tissue inhibitor of metalloproteinases-l (TIMP-l), the major physiological matrix metalloproteinase inhibitor and a potent antimetastatic factor, also stimulates the growth of erythroid progenitors (erythroid-potentiating activity). We analyzed the relationship between the growth factor activity and protease inhibition by preparing purified TIMP-1 “knockout” proteins lacking in vitro antiproteo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of General Physiology
دوره 26 شماره
صفحات -
تاریخ انتشار 1943